Complex I / NADH Dehydrogenase
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 40 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 40 genes have a known function matching the annotation |
Why this annotation
Top hub genes include multiple Complex I subunits (NDUFS7, NDUFV1, NDUFB5, NDUFS3, NDUFB1), ATP synthase (ATP5F1A), TCA cycle enzyme (SUCLG1), and mitoribosome proteins (MRPS34, MRPL12, MRPL24, MRPL34), plus mitochondrial methyltransferase ANTKMT. Mild enrichment in prolif_mac for some genes. AHCY (methionine cycle) and APEX1 (DNA repair) are peripheral. The module is dominated by mitochondrial respiratory chain Complex I and associated mitochondrial translation machinery.
Genes
AHCY, ANP32A, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME, CCDC85B, CLNS1A, CORO1B, CUTA, DCXR, DMAC1, HMGN3, ISOC2, MRPL11, MRPL12, MRPL23, MRPL24, MRPL34, MRPS34, NDUFA10, NDUFB1, NDUFB5, NDUFS3, NDUFS7, NDUFV1, PHB1, POP5, REX1BD, RWDD1, SERPINB6, SKIC8, SUCLG1, TCEAL8, TMEM141, TXN2, UBAC1, ZCRB1
Most correlated modules
- ER Protein Glycosylation · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
- Spliceosomal snRNP · correlation 0.91
- Glycolytic Metabolism · correlation 0.90
- Mitochondrial Biogenesis · correlation 0.90
- Mitochondrial Complex Assembly · correlation 0.89
- Ribosome Biogenesis · correlation 0.89
- Mitotic Spindle Assembly · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.