AHCY — Adenosylhomocysteinase
AHCY belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AHCY's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Basal Lipid Metabolism Housekeeping | ACOT7, ADCY3, CLN6, DENND6B, FANCL, MGLL, MPST, NUDT8 +6 more | |
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | ANP32A, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME, CCDC85B +31 more | View in SCUBA |
| Monocytes | Biosynthetic Metabolic Activation Housekeeping | EEF1B2, IMPDH2, NME1, NPM1, NUCKS1, PABPC4, PEBP1, PRDX4 +4 more | View in SCUBA |
About the gene
| Synonyms | AdoHcyase, SAHH |
|---|---|
| Chromosome | 20: 34280268-34311802 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | One-carbon metabolism |
Function
Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine. Binds copper ions (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.