ARL2 — ADP ribosylation factor like GTPase 2
ARL2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Housekeeping Mitochondrial & OxPhos | BRAT1, C11orf58, CCDC115, CD3E, CHMP4A, CHURC1, DPM3, HAX1 +13 more | |
| Hematopoietic progenitor cells | Chaperonin TRiC Complex Housekeeping | CCDC85B, CCT2, CCT3, CCT5, CCT6A, GADD45GIP1, NDUFS5, NUDC +4 more | |
| Lymphatic endothelial | Mitochondrial OxPhos Complex Mitochondrial & OxPhos | BLOC1S1, CHMP2A, CHURC1, COX5B, DCTN3, FIS1, MRPL43, NDUFA11 +5 more | View in SCUBA |
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | AHCY, ANP32A, ANTKMT, APEX1, ATIC, ATP5F1A, ATP5ME, CCDC85B +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFRP1, ATP6V0E1, CALHM2, CCS, COA4, DBP, DENND2D, DMAC1 +15 more | |
| Smooth muscle cells | ER-Golgi Secretory Protein processing & ER | ATP2A2, BMP2, CD46, LAMB2, PLXND1, RNASEH2C, SPTB, YIF1A | View in SCUBA |
About the gene
| Synonyms | ARFL2 |
|---|---|
| Chromosome | 11: 65014160-65022184 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Also regulates mitochondrial integrity and function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.