WWC3 — WWC family member 3
WWC3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WWC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | PI3K Migration Signaling Migration & adhesion | CPPED1, CREB5, CYTIP, PELI1, PTEN, RASSF3, SEMA4D, SH2D3C +3 more |
About the gene
| Synonyms | BM042, KIAA1280 |
|---|---|
| Chromosome | X: 10015254-10144474 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.