SCUBA

CYTIP — Cytohesin 1 interacting protein

CYTIP belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CYTIP's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsBCR Signaling Regulation
BCR/AP1/NFKb pathway
CBLB, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, IVNS1ABP, MOB3A +5 moreView in SCUBA
CD4⁺ T cellsChemokine Migration
migration & adhesion
CCR6, DDX24, FRMD4B, G3BP2, GNG2, GPBP1, KMT2E, PDE4B +7 moreView in SCUBA
Gamma-delta T cellsmRNA Splicing Regulation
RNA processing & translation
ARF6, BTG3, CAPN7, CDV3, CELF2, CNBD2, CUL3, ELF1 +18 more
Hematopoietic progenitor cellsRegulatory T-cell State
Lymphcyte development
CLEC2D, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A, NEGR1 +9 more
MacrophagesOsmotic Stress Response
Stress
ANKRD28, BZW1, CD109, CXCL8, CYB5R4, DUSP4, EMP3, FURIN +25 moreView in SCUBA
MonocytesMyeloid Innate Receptor Signaling
Innate immunity
HCK, JPT1, LILRA5, LILRB2, MYD88, PAG1, PILRA, SERPINA1View in SCUBA
Mucosal-associated invariant T cellTissue Residency Regulation
Tissue residence
ABCC1, ANKRD28, ARHGEF7, CA2, CDV3, CHD7, IL18R1, JMY +4 more
NeutrophilsPI3K Migration Signaling
Migration & adhesion
CPPED1, CREB5, PELI1, PTEN, RASSF3, SEMA4D, SH2D3C, SIRPB2 +3 more

About the gene

SynonymsB3-1, CASP, CYBR, CYTHIP, HE, PSCDBP
Chromosome2: 157414619-157488961
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins

Function

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.