PI3K Migration Signaling
Gene co-expression module in Neutrophils
| Category | Migration & adhesion |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes SEMA4D, CYTIP, PTEN, and PELI1 collectively point to PI3K/PTEN-regulated integrin and semaphorin signaling controlling neutrophil migration and adhesion. CYTIP directly regulates integrin activation via cytohesin; PTEN antagonizes PI3K-driven chemotaxis; SEMA4D provides repulsive/attractive guidance cues; SIRPB2 and SH2D3C are additional signaling scaffolds. XPO6 exports actin-binding profilin, linking to cytoskeletal remodeling for migration. PELI1 modulates inflammatory signal amplitude. Together these form a coherent migration-regulatory program.
Genes
CPPED1, CREB5, CYTIP, PELI1, PTEN, RASSF3, SEMA4D, SH2D3C, SIRPB2, VMP1, WWC3, XPO6
Most correlated modules
- Endocytic Vesicle Trafficking · correlation 0.97
- Granulopoiesis Transcriptional · correlation 0.97
- Mature Neutrophil Identity · correlation 0.96
- ER Stress Response · correlation 0.95
- TLR5 Bacterial Sensing · correlation 0.95
- Endosomal Vesicle Trafficking · correlation 0.95
- Endosomal Vesicle Trafficking · correlation 0.95
- Ubiquitin-Proteasome Turnover · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.