PELI1 — Pellino E3 ubiquitin protein ligase 1
PELI1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PELI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAPK feedback signaling TCR/AP1/NFKb pathway | BACH1, DUSP16, DUSP4, E2F3, EPSTI1, MAT2B, PIM2, SEC14L1 +2 more | View in SCUBA |
| Enterocytes | STAT3/JNK signaling Inflammation | CDC42SE2, ETV6, KIAA0232, LRRC1, MAPK8, PDLIM5, STAT3, STK24 | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Lymphatic endothelial | NF-κB Innate Signaling Inflammation | AKAP13, B4GALT5, BACH1, CHD2, CNST, DENND5A, HIVEP1, HIVEP2 +11 more | View in SCUBA |
| Macrophages | Transcriptional Kinase Regulation Housekeeping | BNC2, CABLES1, CACNB4, CDK8, ENOX2, FAF1, FOXO1, INPP4B +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Epigenetic Chromatin Regulation DNA/chromatin regulation | ASXL1, CREBBP, FNIP1, GATAD2A, PNRC1, RAPGEF1, RYBP, ZCCHC2 +1 more | |
| Neutrophils | PI3K Migration Signaling Migration & adhesion | CPPED1, CREB5, CYTIP, PTEN, RASSF3, SEMA4D, SH2D3C, SIRPB2 +3 more |
About the gene
| Chromosome | 2: 64092652-64144420 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (By similarity). Mediates 'Lys- 63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Conjugates 'Lys-63'- linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1. Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination. Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.