ZBED2 — Zinc finger BED-type containing 2
ZBED2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZBED2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADGRG1, ATP8B4, CCL3, CCL4, CCL4L2, CSF2, FASLG, GNLY +10 more | View in SCUBA |
| CD8⁺ T cells | T Cell Activation TCR Signaling | BIRC3, CRTAM, DUSP5, GADD45G, GEM, HSP90B1, HSPA5, ID3 +9 more | View in SCUBA |
About the gene
| Synonyms | MGC10796 |
|---|---|
| Chromosome | 3: 111592900-111595346 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional regulator which has intrinsic repressor activity and which competes with the transcriptional activator IRF1 for binding to the 5'-[CA]GAA[AC]C[CT]-3' consensus sequence in gene promoters. May thereby play a role in keratinocyte differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.