DUSP5 — Dual specificity phosphatase 5

DUSP5 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DUSP5's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	TNF/NF-kB response BCR/AP1/NFKb pathway	ADGRE5, ATF3, BHLHE40, CHD1, CMTM6, CYLD, FMNL1, IRF2BP2 +7 more	View in SCUBA
CD4⁺ T cells	Effector activation NFkB TCR/AP1/NFKb pathway	ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, ETF1, HIPK1 +23 more	View in SCUBA
CD8⁺ T cells	T Cell Activation TCR Signaling	BIRC3, CRTAM, GADD45G, GEM, HSP90B1, HSPA5, ID3, IL13 +9 more	View in SCUBA
Fibroblasts	NF-κB Epigenetic Reprogramming Inflammatory	BCL3, BTG2, CDKN1A, CSRNP1, EGR2, KDM6B, KLF10, LDLR +3 more	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1, NFKB2 +13 more
Innate lymphoid cells	Cytokine-driven Activation activation	BIRC3, CALR, CD69, GADD45G, ISG15, NCOA7, PPIF, RUNX3 +2 more	View in SCUBA
Lymphatic endothelial	Stress Granule Assembly Stress	AMD1, BHLHE40, CD55, CDKN1A, DDX3X, EIF4G2, ERF, FUS +3 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Activation Inflammation	DUSP8, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1, PER1 +8 more
Pericytes	Proteotoxic Stress Response Stress	BAG3, CDKN1A, DDX3X, DNAJA4, HES1, HSPH1, SLC2A3, TRA2B +1 more	View in SCUBA

About the gene

Synonyms	HVH3
Chromosome	10: 110497907-110511533
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Predicted intracellular proteins
Molecular function	Hydrolase, Protein phosphatase

Function

Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.