BIRC3 — Baculoviral IAP repeat containing 3

BIRC3 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

BIRC3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NFkB/MAPK activation BCR/AP1/NFKb pathway	CCDC107, CD72, CHI3L2, CLEC2B, DENND4A, LRRFIP1, MAP3K8, MYADM +7 more	View in SCUBA
CD4⁺ T cells	TNF/NF-kB activation TCR/AP1/NFKb pathway	DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1, RBBP8 +6 more	View in SCUBA
CD8⁺ T cells	T Cell Activation TCR Signaling	CRTAM, DUSP5, GADD45G, GEM, HSP90B1, HSPA5, ID3, IL13 +9 more	View in SCUBA
Endothelial	Leukocyte Recruitment Signaling Inflammation	CELSR1, CSF2RB, HAPLN3, HSD3B7, IL34, IL7R, LTF, OLFM1 +6 more	View in SCUBA
Enterocytes	IFN-gamma response Inflammation	APOL6, GBP1, GBP2, IRF1, NUB1, PARP14, PARP9, RNF213 +2 more	View in SCUBA
Fibroblasts	NF-κB Inflammatory Activation Inflammatory	CD40, CTSS, DRAM1, HAPLN3, IL15RA, IL32, LAP3, STAT1 +5 more	View in SCUBA
Gamma-delta T cells	AHR/NF-κB Survival Immune regulation	ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, CBL +24 more
Glial cells	NF-κB/IFN Inflammatory Inflammation	CTSS, CXCL10, CXCL2, CXCL9, FDCSP, HAPLN3, ICAM1, PTX3 +4 more	View in SCUBA
Goblet cells	DUOX2 Epithelial Inflammation Stress	AKAP13, DUOX2, DUOXA2, DUSP4, IL2RG, IL32, ISG15, RNF213 +1 more	View in SCUBA
Innate lymphoid cells	Cytokine-driven Activation activation	CALR, CD69, DUSP5, GADD45G, ISG15, NCOA7, PPIF, RUNX3 +2 more	View in SCUBA
Macrophages	NF-κB Effector Response Inflammatory	ARL5B, CYB5D1, DUSP2, EGR3, HES1, ICAM4, PTGS2, SIK1	View in SCUBA
Monocytes	NF-κB Signaling Inflammatory	ERN1, G0S2, ICAM1, IER3, IRAK2, NFKB1, PDE4B, PNRC1 +4 more	View in SCUBA
Mucosal-associated invariant T cell	Metabolic Homeostasis Housekeeping	ADIPOR1, COQ10B, CREBRF, EIF1AX, GNAI3, H2AC20, KLF11, KLHL18 +10 more
Natural Killer cells	NF-κB Activation Inflammation	ARL5B, CD83, KDM6B, NFKBID, NR4A1, NR4A3, RASGEF1B, REL	View in SCUBA

About the gene

Synonyms	API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49
Chromosome	11: 102317450-102339403
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Transferase
Biological process	Apoptosis, Ubl conjugation pathway

Function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.