GEM — GTP binding protein overexpressed in skeletal muscle
GEM belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GEM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative/ER stress Stress | ASAH1, ATP6V0D1, B4GALT1, FAM210A, FOSL2, GZF1, HIC1, MAFG +6 more | View in SCUBA |
| CD4⁺ T cells | Treg regulation Immune regulation | BCAS3, CDK14, CEBPA, CLNK, CNIH1, COL9A2, CPA5, FCRL3 +8 more | View in SCUBA |
| CD8⁺ T cells | T Cell Activation TCR Signaling | BIRC3, CRTAM, DUSP5, GADD45G, HSP90B1, HSPA5, ID3, IL13 +9 more | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GRAMD2B, HMOX1 +14 more | |
| Glial cells | Inflammatory Activation Response Inflammation | ANGPTL4, C11orf96, CD83, CEBPD, ENY2, IDI1, IRF9, LMO4 +3 more | View in SCUBA |
| Natural Killer cells | NK Tissue Residency Gut residency | ENTPD1, GPR171, ITGA1, KLHL23, LDLRAD4, PHYKPL, RCAN3 | View in SCUBA |
| Pericytes | Cytokine Inflammatory Response Inflammatory | ADAMTS4, C11orf96, CEBPB, CEBPD, ID4, KCNE4, PHLDA1, RGS16 +4 more | View in SCUBA |
About the gene
| Synonyms | KIR |
|---|---|
| Chromosome | 8: 94249253-94262350 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Calmodulin-binding |
Function
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.