T Cell Activation
Gene co-expression module in CD8⁺ T cells
| Category | TCR Signaling |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
Top hub TNFRSF9 (4-1BB) is a canonical T cell co-stimulatory/activation receptor. GEM, RGS16, DUSP5, SGK1, BIRC3 are all well-documented TCR activation-induced immediate-early response genes. CRTAM marks activated cytotoxic T cells. SERPINB9 is expressed in activated effectors. GADD45G, PIM3, MAP2K3 reflect MAPK/stress-linked activation signaling. TNFSF4 and IL13 suggest broader effector activation. The module represents a coherent TCR/co-stimulation-driven T cell activation program.
Genes
BIRC3, CRTAM, DUSP5, GADD45G, GEM, HSP90B1, HSPA5, ID3, IL13, MAP2K3, PDLIM4, PIM3, RGS16, SERPINB9, SGK1, TNFRSF9, TNFSF4, ZBED2
Most correlated modules
- Proliferating CD8 T cell · correlation 0.86
- BATF-driven Activation · correlation 0.86
- Cytotoxic Exhausted CD8 · correlation 0.81
- Tumor mediated exhaustion · correlation 0.80
- Heat Shock Response · correlation 0.76
- T cell Immune Tolerance · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.