ZBTB8OS — Zinc finger and BTB domain containing 8 opposite strand
ZBTB8OS belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZBTB8OS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CCR5 effector migration migration & adhesion | ARHGEF12, BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12 +10 more | View in SCUBA |
| Macrophages | Glycolytic Redox Metabolism Lipid metabolism | AGPAT2, ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC +18 more | View in SCUBA |
About the gene
| Synonyms | ARCH |
|---|---|
| Chromosome | 1: 32600172-32650903 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | tRNA processing |
Function
Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.