Glycolytic Redox Metabolism
Gene co-expression module in Macrophages
| Category | Lipid metabolism |
|---|---|
| Genes | 27 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes PKM (pyruvate kinase M2/glycolysis), GAPDH (glycolysis), TALDO1 (transaldolase/pentose phosphate pathway), GSTO1 (glutathione S-transferase omega/oxidative stress), GPX4 (glutathione peroxidase 4/ferroptosis defense), TXN (thioredoxin/redox), ATP6V1F (V-ATPase), CLIC1 (chloride intracellular channel/redox sensor), LGALS3 (galectin-3, macrophage activation marker), PLA2G7 (PAF acetylhydrolase/lipid metabolism), AGPAT2 (lysophospholipid acyltransferase). Several genes are enriched in mono_mac (LGALS3 3.9x, PLA2G7 3.7x, TXN 2.8x, PKM, GSTO1, ATP6V1F). This module captures a metabolic/redox program characteristic of monocyte-derived macrophages, combining glycolysis, pentose phosphate pathway, and antioxidant defense — consistent with the metabolic state of inflammatory monocyte-macrophages.
Genes
AGPAT2, ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC, ENO1, GAPDH, GNG5, GPR108, GPX4, GSTO1, LGALS3, MFSD10, NDUFB4, NOP10, PKM, PLA2G7, RAB5IF, S100A11, TALDO1, TMEM167A, TMEM70, TXN, ZBTB8OS
Most correlated modules
- Proteasome UPS · correlation 0.95
- Proteasome UPS · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.94
- ERAD Proteasome · correlation 0.93
- Mixed Housekeeping · correlation 0.91
- ER Protein Processing · correlation 0.90
- ATP Synthase Complex · correlation 0.90
- ER Protein Translocation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.