ATP6V1F — ATPase H+ transporting V1 subunit F
ATP6V1F belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V1F's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteostasis OxPhos Housekeeping | AIP, ARPC1B, C4orf48, CHMP2A, IL2RG, NDUFA13, NDUFB10, PPP1R7 +6 more | View in SCUBA |
| CD8⁺ T cells | RNA Splicing Complex RNA processing & translation | ATP6V0B, EIF3I, MRPS6, NDUFS7, PARK7, PRDX6, PSMD4, SF3B5 +3 more | View in SCUBA |
| Gamma-delta T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ARPC1B, ARPC4, COPE, COX6A1, COX6B1, COX6C, CSNK2B, NDUFA1 +12 more | |
| Innate lymphoid cells | Glycolysis & OxPhos Metabolism | ARPC4, BRK1, ENO1, FKBP1A, GAPDH, NEDD8, PYURF, SELENOF +2 more | View in SCUBA |
| Lymphatic endothelial | MHC-I Antigen Presentation Immune regulation | HLA-A, HLA-B, HLA-C, HLA-E, OAZ1, PPP1R14B, PSMB8, PSME1 +2 more | View in SCUBA |
| Macrophages | Glycolytic Redox Metabolism Lipid metabolism | AGPAT2, ANXA5, BCKDK, BRI3, C1orf122, CLIC1, ELOC, ENO1 +18 more | View in SCUBA |
About the gene
| Synonyms | ATP6S14, VATF, Vma7 |
|---|---|
| Chromosome | 7: 128862856-128865847 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted intracellular proteins, Transporters |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.