AGPAT2 — 1-acylglycerol-3-phosphate O-acyltransferase 2
AGPAT2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGPAT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ADAM23, CLDN5, ECHDC2, GOLGA8B, HHEX, LY6E, NDN, PERP +1 more | View in SCUBA |
| Macrophages | Glycolytic Redox Metabolism Lipid metabolism | ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC, ENO1 +18 more | View in SCUBA |
About the gene
| Synonyms | BSCL, LPAAT-beta, LPLAT2 |
|---|---|
| Chromosome | 9: 136673143-136687457 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.