ZNF467 — Zinc finger protein 467
ZNF467 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZNF467's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Myeloid Commitment Myeloid development | ADA, ALDH2, CTSD, DENND6B, HCST, LAIR1, LST1, NINJ1 +4 more | |
| Neutrophils | Neutrophil Motility Cytoskeleton Migration & adhesion | CDKN2D, CNN2, COTL1, CST7, GLIPR1, GMFG, GNB2, GPSM3 +9 more |
About the gene
| Synonyms | EZI, Zfp467 |
|---|---|
| Chromosome | 7: 149764182-149773588 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.