HCST — Hematopoietic cell signal transducer
HCST belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HCST's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | ER/vesicle trafficking Protein processing & ER | ATP6V0B, CD99, DIAPH1, M6PR, MTDH, MTPN, REEP5, SCPEP1 +1 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Effector cytotoxicity | APOBEC3H, B2M, CCL4, CCL5, CD52, CYBA, GZMH, HLA-A +4 more | View in SCUBA |
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, GABARAP, HDAC10, IER3IP1, IL2RG, KLRK1, KRTCAP2, LAMTOR4 +11 more | |
| Hematopoietic progenitor cells | Myeloid Commitment Myeloid development | ADA, ALDH2, CTSD, DENND6B, LAIR1, LST1, NINJ1, NUDT8 +4 more | |
| Innate lymphoid cells | NK Homing Circulating Homing & TEM | ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more | View in SCUBA |
| Mucosal-associated invariant T cell | Leukocyte Housekeeping Housekeeping | AP2S1, APRT, ATP5MC2, CCDC85B, EIF3G, ERP29, GABARAPL2, GMFG +5 more | |
| Natural Killer cells | NK Cytotoxic Signaling Cytotoxicity | APOBEC3G, B2M, CALM1, CD48, GLIPR2, MYL12A, TMSB10, TRGC1 +1 more | View in SCUBA |
About the gene
| Synonyms | DAP10, DKFZP586C1522, KAP10, PIK3AP |
|---|---|
| Chromosome | 19: 35902529-35904377 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR- induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.