Myeloid Commitment
Gene co-expression module in Hematopoietic progenitor cells
| Category | Myeloid development |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub CTSD is a lysosomal cathepsin highly expressed in myeloid/monocytic cells and marks monocyte-lineage commitment. HCST (DAP10) is a signaling adaptor for myeloid and NK receptors. LAIR1 and VSIR are inhibitory immune receptors expressed on myeloid and NK cells. LST1 is a classical myeloid leukocyte marker. ADA (adenosine deaminase) marks lymphoid and myeloid progenitors. SPNS3 is a sphingolipid transporter active in myeloid differentiation. NINJ1 mediates cell adhesion during myeloid inflammatory responses. ALDH2 is expressed in myeloid progenitors. Together these define a myeloid-committed HPC substate with monocytic lineage features and immune modulatory receptor expression.
Genes
ADA, ALDH2, CTSD, DENND6B, HCST, LAIR1, LST1, NINJ1, NUDT8, SDK2, SPNS3, VSIR, ZNF467
Most correlated modules
- Naive B Cell · correlation 0.88
- Lymphoid-Primed Progenitor · correlation 0.88
- Multipotent Progenitor Identity · correlation 0.88
- HOX HSC Program · correlation 0.85
- Quiescent HSC State · correlation 0.85
- Lymphoid Progenitor TFs · correlation 0.84
- Lymphoid Progenitor Commitment · correlation 0.83
- T/NK Cell Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.