ALDH2 — Aldehyde dehydrogenase 2 family member
ALDH2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ALDH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia Stress Response Stress | ABCA5, BAALC, CIRBP, EGLN3, EPB41, FARP1, FTL, LRP5 +7 more | View in SCUBA |
| Fibroblasts | Metabolic Homeostasis Housekeeping | ADH5, ATP2B1, ISCU, NBL1, NLGN4X, PGM1, PKIG, RAB7A +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Myeloid Commitment Myeloid development | ADA, CTSD, DENND6B, HCST, LAIR1, LST1, NINJ1, NUDT8 +4 more | |
| Lymphatic endothelial | Oxidative Stress Protection Stress | ANAPC16, BCL7C, CAVIN2, CCL21, CD320, CRACR2B, FXYD6, GUSB +10 more | View in SCUBA |
| Smooth muscle cells | Integrin adhesion complex Migration & adhesion | ALDH1B1, DST, FERMT2, ITGA5, KLHL42, METTL7A, NFIX, NPTN +3 more | View in SCUBA |
About the gene
| Chromosome | 12: 111766887-111817532 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.