LST1 — Leukocyte specific transcript 1
LST1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LST1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, ARHGEF3, CD226, CD52, DENND3, EVL, IDH2, IL17RE +13 more | View in SCUBA |
| Gamma-delta T cells | γδT17 Effector Inflammation | AQP3, CCR6, CEBPD, COLQ, CTSA, CTSH, EDEM2, GCHFR +10 more | |
| Hematopoietic progenitor cells | Myeloid Commitment Myeloid development | ADA, ALDH2, CTSD, DENND6B, HCST, LAIR1, NINJ1, NUDT8 +4 more | |
| Innate lymphoid cells | ILC-1 identity Differentiation | ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 more | View in SCUBA |
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mucosal MAIT Homing migration & adhesion | BLK, BRD9, CCR6, DSEL, ERN1, FUT7, LGALS3, LPAR6 +5 more | |
| Neutrophils | Myeloid Identity Housekeeping | ANP32A, CKLF, CMTM2, HLA-C, HLA-E, IFITM2, ITM2B, MYL12A +3 more |
About the gene
| Synonyms | B144, D6S49E, LST-1 |
|---|---|
| Chromosome | 6: 31586124-31588909 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Cell shape, Immunity |
Function
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.