ADA — Adenosine deaminase
ADA belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 lineage Th17 fate | ARHGEF3, CD226, CD52, DENND3, EVL, IDH2, IL17RE, IL23R +13 more | View in SCUBA |
| Hematopoietic progenitor cells | Myeloid Commitment Myeloid development | ALDH2, CTSD, DENND6B, HCST, LAIR1, LST1, NINJ1, NUDT8 +4 more | |
| Monocytes | G-protein Membrane Remodeling Migration & adhesion | ANKRD9, CXCL16, DNMBP, EPB41L3, GFOD1, GNA12, GNA13, MRAS +7 more | View in SCUBA |
| Pericytes | Basement Membrane Remodeling ECM remodeling | C4orf48, CYBA, DKK3, EFEMP2, G0S2, ISG20, LAMB3, RCN3 +2 more | View in SCUBA |
About the gene
| Synonyms | ADA1 |
|---|---|
| Chromosome | 20: 44584896-44652252 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Cell adhesion, Nucleotide metabolism |
Function
Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.