Integrin Adhesion Migration
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub and core genes are dominated by adhesion/cytoskeletal migration machinery: ITGAE (CD103, tissue-resident integrin), MSN (moesin), TLN1 (talin), FERMT3 (kindlin-3, integrin activation), MACF1, DIAPH1 (actin nucleator), COTL1, TAGAP (T-cell GTPase). This is an integrin-mediated adhesion/migration program characteristic of tissue-resident memory CD4 T cells. Upregulated in inflammation. Some interferon (LY6E) and chromatin (HMGB1, DEK) peripheral members.
Genes
ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1, EML4, FERMT3, GNB1, HMGB1, ITGAE, LY6E, MACF1, MSN, SCP2, SMCO4, TAGAP, TLN1
Most correlated modules
- Effector Immune Activation · correlation 0.86
- Actin Cytoskeleton · correlation 0.82
- Oxidative Phosphorylation · correlation 0.81
- Oxidative phosphorylation · correlation 0.78
- RNA & Chromatin Regulation · correlation 0.76
- Chromatin regulation · correlation 0.75
- Rho-GTPase Migration · correlation 0.74
- PD-L1 checkpoint · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.