TRIM28-ZNF Repression
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 16 genes have a known function matching the annotation |
Why this annotation
A heterogeneous module with chromatin/transcriptional regulators (TRIM28, ZNF721, ZNF91, ISG20L2), stress/kinase signaling (HSPA2, MAP3K13, PLK2), metabolic/transport (PHYH, SLC38A2, B4GALT4), and trafficking (EEA1). No single dominant program; the most central genes are KRAB-zinc finger/TRIM28 transcriptional repression machinery (TRIM28, ZNF721, ZNF91) plus stress-response elements. Given the mix and TRIM28 hub, the best-supported coherent theme is chromatin/transcriptional regulation, though confidence is low.
Genes
B4GALT4, EEA1, FSCN1, HSPA2, ISG20L2, MAP3K13, MLF1, MORN3, PABPC4, PHYH, PLK2, SLC38A2, TRIM28, USP25, ZNF721, ZNF91
Most correlated modules
- T cell Coinhibition · correlation 0.72
- Vesicle trafficking · correlation 0.56
- Pol II Transcription Regulation · correlation 0.51
- DNA damage response · correlation 0.49
- Integrated Stress Response · correlation 0.48
- Hypoxia metabolic stress · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.