Inflammatory activation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes GFI1 (transcription factor regulating Th17/T cell differentiation), TNFRSF1A (TNF receptor), GBP3 (interferon-induced GTPase), P2RY11, GPR34 (purinergic/lipid GPCRs), UNC13D (cytotoxic degranulation). Strong positive correlation with inflammation in UC and CD. Mix of inflammatory signaling and TF; GFI1 + TNFRSF1A + GBP3 point to an inflammatory T cell activation program. Neighbor of Th17 modules; GFI1 is Th17-relevant.
Genes
ATF7IP2, ATP10D, B3GALT2, COMMD8, GBP3, GFI1, GPR34, MAEA, MGAT1, P2RY11, PLEKHF1, ST3GAL5, TNFRSF1A, TOGARAM2, TRPM2, UNC13D
Most correlated modules
- Th17 effector · correlation 0.84
- Rho-GTPase Migration · correlation 0.82
- Th17 lineage · correlation 0.80
- TCR Complex Activation · correlation 0.76
- Gamma-delta T cell · correlation 0.75
- Cytotoxic effector · correlation 0.75
- Immune regulation · correlation 0.72
- Actin Cytoskeleton · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.