NF-kB feedback
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes TNIP3 (TNFAIP3-interacting, NF-kB inhibitor), N4BP1 (NF-kB/immune regulator), CLEC7A (Dectin-1), TRIB2, MAP3K5 (ASK1), CDKN2A (senescence). TNIP3 and N4BP1 are NF-kB negative regulators strongly induced by inflammatory signaling, SKAP1 is a TCR adaptor. Strong inflammation association and treatment reversal. Represents NF-kB-driven inflammatory activation with feedback inhibitors.
Genes
ADTRP, AKAP5, CDIP1, CDKN2A, CLEC7A, INPP1, MAP3K5, N4BP1, PBXIP1, PHTF2, RPS27L, SETBP1, SKAP1, TNIP3, TRIB2, UBE2H, ZNF282
Most correlated modules
- Activated effector Tcell · correlation 0.93
- MAPK feedback signaling · correlation 0.93
- Inflammatory activation · correlation 0.88
- Activated Treg · correlation 0.83
- Cell cycle regulators · correlation 0.83
- Actomyosin signaling · correlation 0.83
- Th1 IL12 response · correlation 0.82
- mRNA stability regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.