Activated effector Tcell
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRDM1 (BLIMP1, terminal effector/Treg differentiation), ENTPD1 (CD39, marker of activated/regulatory and tissue-resident T cells), IL2RB, CTSC, APOBEC3C. This is an activated/effector CD4 T cell module strongly upregulated in inflamed UC/CD and reversed in remission. PRDM1 + ENTPD1 + IL2RB point to a chronically activated effector/regulatory tissue-resident program rather than a single canonical pathway. The inflammation-associated activation signature dominates.
Genes
APOBEC3C, ARPP19, CISD2, CTSC, ENTPD1, GLUD1, IL2RB, LYST, MICAL2, PMVK, PRDM1, SSH1, TAX1BP1
Most correlated modules
- NF-kB feedback · correlation 0.93
- MAPK feedback signaling · correlation 0.91
- Proteasome translation · correlation 0.91
- Th1 IL12 response · correlation 0.89
- Activated Treg · correlation 0.89
- Inflammatory activation · correlation 0.88
- Actomyosin signaling · correlation 0.88
- Mitochondrial OxPhos · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.