RNA & Chromatin Regulation
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Mixed module of RNA processing/transcription and chromatin regulators: DCP2 (decapping/mRNA decay), HNRNPLL (T-cell splicing regulator, CD45 isoforms), TCEA1 (transcription elongation), ATRX, KDM5B, NCOR1 (chromatin/transcription corepressors), RIOK3, SMC4 (condensin). Also interferon-related SAMD9, TRIM38. Hub DCP2 plus HNRNPLL and chromatin regulators point to RNA processing/transcriptional regulation. Upregulated in inflammation.
Genes
ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3, SAMD9, SMC4, TCEA1, TMBIM4, TRIM38, TSPAN14, UBE2K, WNK1
Most correlated modules
- Chromatin regulation · correlation 0.91
- Effector Immune Activation · correlation 0.88
- Epigenetic regulation · correlation 0.84
- Oxidative phosphorylation · correlation 0.84
- PD-L1 checkpoint · correlation 0.83
- Oxidative Phosphorylation · correlation 0.81
- Oxidative Phosphorylation · correlation 0.80
- Chromatin transcription regulation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.