CCR5 effector migration
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Top hub is CCR5, a chemokine receptor central to Th1 effector trafficking and inflammation, accompanied by immune activation/adhesion markers SLAMF1, RASSF5, RHOF, RAB10/RAB8B (Rho/Rab GTPase trafficking), and TRIM69 (antiviral). The module strongly increases with inflammation in both UC and CD and decreases with treatment, consistent with an inflammatory effector T-cell program. However, the mix of housekeeping genes (BLM, ZBTB24, PSMD12, ERGIC2, TUBB) lowers specificity. Anchored on CCR5/SLAMF1, this reads as an inflammation-associated effector/migration program.
Genes
ARHGEF12, BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12, RAB10, RAB8B, RASSF5, RHOF, SLAMF1, TRIM69, TUBB, UQCC2, VPS13C, ZBTB24, ZBTB8OS
Most correlated modules
- AKT survival signaling · correlation 0.91
- Protein/ER secretory machinery · correlation 0.84
- OxPhos & redox · correlation 0.83
- T cell activation · correlation 0.82
- Cytoskeleton & metabolism · correlation 0.81
- Chromatin transcription regulation · correlation 0.77
- Mitochondrial Translation · correlation 0.76
- CD4 Lineage Identity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.