Unfolded Protein Response
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Top hubs HSPA5 (BiP), ATF4, DDIT3-axis-related genes indicate the ER stress / unfolded protein response (PERK-ATF4 branch). NRIP3, RPL22L1, NXT1, NOP56, SRSF3 add translational/RNA components, but ATF4-HSPA5 anchor it. IL23A and NLRP3 hint at an inflammatory tail, but ER stress dominates the hub structure. Neighbors M131 (XBP1, ATF3), M78 (DDIT3, EIF4A3) and M88 (HSP chaperones) reinforce an integrated stress/UPR neighborhood.
Genes
ARF4, ATF4, DUSP8, HSPA5, IL23A, NLRP3, NOP56, NRIP3, NXT1, PLK3, PRR7, RPL22L1, SH2D3A, SKIL, SRSF3, TSC22D2
Most correlated modules
- Immediate Early AP-1 · correlation 0.85
- Integrated Stress Response · correlation 0.84
- NF-kB Feedback Response · correlation 0.81
- Pol II Transcription Regulation · correlation 0.80
- T cell quiescence · correlation 0.78
- Resting memory T cell · correlation 0.73
- NF-kB activation · correlation 0.68
- TCR signaling · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.