Interferon response
Gene co-expression module in CD4⁺ T cells
| Category | Anti-viral |
|---|---|
| Genes | 32 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 32 genes have a known function matching the annotation |
Why this annotation
Clear interferon-stimulated gene signature: XAF1, GBP1, PARP9, SP100, SP110, SP140L, STAT1, PHF11, MX1, CISH, BTN3A2, BTN2A1, NARF, RNF166. Hubs BTN3A2, XAF1, PDLIM2 (NF-kB regulator). STAT1/MX1/GBP1/SP100/SP110/PARP9 are canonical type I/II interferon response genes. Strongly inflammation-upregulated in IBD, treatment-downregulated. This is an antiviral/interferon response module.
Genes
ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, ERAP2, GBP1, HERC5, LPAR6, MX1, NARF, PARP9, PDLIM2, PHF11, RBM22, RCBTB2, RGS14, RGS19, RNF166, SDF2, SP100, SP110, SP140L, SPNS3, STAT1, THEM6, USP20, XAF1, ZBP1, ZNF276
Most correlated modules
- Immune regulation · correlation 0.69
- Inflammatory effector · correlation 0.67
- DNA repair/replication · correlation 0.66
- Inflammatory activation · correlation 0.62
- Cytokine receptor signaling · correlation 0.61
- Post-transcriptional regulation · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.