Th1 IL12 response
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Contains IL12RB2 (Th1 differentiation receptor), ETV7 (interferon-induced), HIVEP3, PTPN1, AKIRIN2 (NF-kB/inflammatory signaling). IL12RB2 + ETV7 + strong inflammation upregulation suggests a Th1/IL-12 responsive inflammatory effector program. Reversed in remission and reduced by treatment, consistent with inflammation-driven Th1 polarization.
Genes
ADCY3, AKIRIN2, CTNNA1, ETV7, HIVEP3, IL12RB2, JAKMIP1, PTPN1, RFTN1, SNX5, TSPAN17
Most correlated modules
- Activated effector Tcell · correlation 0.89
- Inflammatory activation · correlation 0.88
- Proteasome translation · correlation 0.87
- Activated Treg · correlation 0.85
- MAPK feedback signaling · correlation 0.84
- TNF activation survival · correlation 0.83
- Interferon-stimulated genes · correlation 0.82
- NF-kB feedback · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.