PD-L1 checkpoint
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 22 genes have a known function matching the annotation |
Why this annotation
Hub gene CD274 (PD-L1) is an immune checkpoint, and the module is significantly upregulated in inflamed UC/CD tissue and reduced by treatment. Other genes (ADAM12, TNS3, LASP1, CASS4, INPP5D/SHIP1, SHMT2) are a mix of adhesion/signaling and metabolic genes. Although heterogeneous, the dominant interpretable identity is checkpoint/immune regulatory expression in inflammation, with CD274 anchoring an immune regulation/exhaustion-like program. Given CD274 as a regulatory checkpoint, immune regulation fits best.
Genes
ADAM12, CASS4, CCDC88B, CD274, GALNT10, HUWE1, INPP5D, KIF3B, LASP1, MED8, N4BP2L1, NF2, PEPD, PLEKHG2, S100PBP, SAP30, SEL1L3, SHMT2, SPAG9, TNS3, U2AF1L4, ZCCHC17
Most correlated modules
- Glycosylation & trafficking · correlation 0.97
- Oxidative phosphorylation · correlation 0.95
- Respiratory chain assembly · correlation 0.90
- Epigenetic regulation · correlation 0.88
- Activated Effector ISG · correlation 0.86
- Chromatin regulation · correlation 0.83
- RNA & Chromatin Regulation · correlation 0.83
- Vesicular trafficking · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.