Protein/ER secretory machinery
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 25 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes are broadly housekeeping/biosynthetic: PUF60 (splicing), MAF1 (Pol III repressor), BAZ1B (chromatin), RBX1/UBA3 (ubiquitin/neddylation), COPZ1/SURF4/CNPY2/ERGIC-associated (ER/Golgi trafficking and secretory pathway), ATP5ME/MRPL33/CMC2 (mitochondrial), ACTR2 (actin). This is a mixed metabolic/biosynthetic housekeeping module with no dominant immune program. Coherence likely reflects shared basal cellular machinery upregulated in activated cells (consistent with inflammation correlation).
Genes
ACTR2, ATP5IF1, ATP5ME, BAZ1B, CMC2, CNPY2, COMMD3, COPZ1, CRY1, CSK, DESI2, LARP7, MAF1, MED28, MRPL33, NDUFA1, PUF60, RBX1, SMIM7, SUGT1, SURF4, TRAC, TXNDC15, UBA3, USF2
Most correlated modules
- CCR5 effector migration · correlation 0.84
- T cell activation · correlation 0.82
- AKT survival signaling · correlation 0.80
- Membrane Trafficking · correlation 0.76
- OxPhos & redox · correlation 0.76
- Vesicular trafficking · correlation 0.75
- mRNA Processing · correlation 0.74
- Chromatin transcription regulation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.