NF-kB regulation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
Notable enrichment for NF-kB regulatory genes: OTULIN, CYLD, TSG101, ARIH2, NFAT5, plus DERL1/DAD1 (ERAD). OTULIN and CYLD are key linear-ubiquitin/deubiquitinase NF-kB pathway regulators, and NFAT5 is a stress/osmotic transcription factor in T cells. CD58 is a T-cell costimulatory ligand. Together with TSG101 (ESCRT), this module reflects ubiquitin-dependent NF-kB signaling control in activated CD4 T cells. Inflammation-correlated, treatment-reversible.
Genes
ARIH2, CD58, CYLD, DAD1, DERL1, EED, ELOVL5, NFAT5, OTULIN, OXCT1, PICALM, RAB5IF, SELENOT, SUPT5H, TMEM9B, TSG101, TUT7, ZNF688
Most correlated modules
- Membrane trafficking · correlation 0.92
- Cellular biosynthesis · correlation 0.90
- RNA processing splicing · correlation 0.88
- Proteasome/translation · correlation 0.88
- T-cell activation · correlation 0.87
- Proteostasis OxPhos · correlation 0.87
- ER-Golgi Trafficking · correlation 0.82
- Vesicle trafficking · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.