Mitochondrial Ribosome
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes: MRPS16 (mitochondrial ribosomal protein small subunit), MRPL37 (mitochondrial ribosomal protein large subunit), POP7 (RNase P/MRP subunit involved in mitochondrial RNA processing), BOLA3 (iron-sulfur cluster biogenesis, mitochondrial), EBP (emopamil-binding protein, cholesterol biosynthesis), COPRS (coordinator of PRMT5 and differentiation stimulator), ENSA (endosulfine alpha, cell cycle PP2A regulation), BCL7C (chromatin remodeling). The dominant theme among top-ranked genes is mitochondrial ribosome and RNA processing (MRPS16, MRPL37, POP7, BOLA3). In the context of the mitochondrial neighbor modules (M85, M78, M27, M2), this fits squarely as a mitochondrial ribosome/translation module.
Genes
Most correlated modules
- Mitochondrial Assembly · correlation 0.93
- Nuclear Assembly · correlation 0.90
- Housekeeping Mixed · correlation 0.90
- OxPhos & Mito Import · correlation 0.89
- Mitochondrial Ribosome · correlation 0.88
- Mitochondrial OXPHOS · correlation 0.87
- Core Cellular Machinery · correlation 0.87
- Metabolic Enzyme Housekeeping · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.