Proteasome Ubiquitin Degradation
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
PSMA4, PSMB6, PSMB3 are alpha and beta proteasome subunits; PSMG2 is a proteasome assembly chaperone. UBB (ubiquitin B) provides the ubiquitin tag for proteasomal degradation. TXNDC17 (thioredoxin domain-containing 17) regulates proteasome activity via redox. MRFAP1 interacts with MORF4L1 and chromatin-ubiquitin pathways. NUTF2 mediates nuclear import of RanGDP, necessary for recycling ubiquitinated cargo signals. PFN1 and VPS29 are peripheral members. The core is clearly the 26S proteasome/ubiquitin degradation pathway.
Genes
Most correlated modules
- Oxidative Phosphorylation ETC · correlation 0.94
- Core Cellular Machinery · correlation 0.91
- Aerobic Glycolysis Warburg · correlation 0.88
- ER Protein Processing · correlation 0.87
- Metabolic Enzyme Housekeeping · correlation 0.86
- Mitochondrial Assembly · correlation 0.85
- Actin Cytoskeleton Regulation · correlation 0.84
- OxPhos & Mito Import · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.