Oxidative Phosphorylation ETC
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
The module is dominated by core ETC subunits: NDUFA6, NDUFS5, NDUFC1 (Complex I), UQCR10 (Complex III), COX5A and COX8A (Complex IV). MRPL41 is a mitoribosomal protein supporting mitochondrial translation of ETC components. SOD1 and CISD2 handle ROS and iron-sulfur cluster integrity respectively, both mitochondrial functions. RBX1 is a ubiquitin E3 ligase component; DDT is a D-dopachrome tautomerase with reported mitochondrial links. This is a tight oxidative phosphorylation / electron transport chain module.
Genes
Most correlated modules
- Proteasome Ubiquitin Degradation · correlation 0.94
- Metabolic Enzyme Housekeeping · correlation 0.88
- ER Protein Processing · correlation 0.87
- Core Cellular Machinery · correlation 0.86
- OxPhos Complex III/IV · correlation 0.86
- OxPhos & Mito Import · correlation 0.85
- Mitochondrial Assembly · correlation 0.84
- Actin Cytoskeleton Regulation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.