Aerobic Glycolysis Warburg
Gene co-expression module in Colorectal carcinoma
| Category | Glycolysis & Warburg effect |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
TPI1 (triosephosphate isomerase), ENO1 (enolase), PGAM1 (phosphoglycerate mutase), LDHA (lactate dehydrogenase A), and GAPDH are canonical glycolytic enzymes central to the Warburg effect in CRC. S100A6 and TMSB10/TAGLN2 are actin-cytoskeletal proteins frequently co-expressed with glycolytic programs in cancer. HMGA1 is a chromatin architectural protein that upregulates glycolytic gene transcription. EIF5A and EIF4A1 are translation factors whose co-expression likely reflects the high biosynthetic demand of Warburg-active cells. The moderate coherence reflects this mixed glycolytic/housekeeping composition, but the glycolytic core is strong.
Genes
Most correlated modules
- Proteasome Ubiquitin Degradation · correlation 0.88
- Endosomal Vesicle Recycling · correlation 0.84
- Oxidative Phosphorylation ETC · correlation 0.83
- Epithelial S100/Keratin · correlation 0.82
- Metabolic Stress Response · correlation 0.75
- Metabolic Enzyme Housekeeping · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.