Pre-mRNA Splicing
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes LUC7L3, PNISR, ARGLU1, PNN, RSRP1 are all SR-protein family or SR-related RNA splicing factors. FUS is a well-known RNA binding protein involved in pre-mRNA splicing and processing. POLR2J3 encodes an RNA Polymerase II subunit linking transcription to splicing. NKTR is involved in nuclear transport of RNA. TAF1D participates in transcription initiation. The module is core-coherent with uniform expression, consistent with a housekeeping splicing/transcription-coupled RNA processing program.
Genes
Most correlated modules
- Golgi-Nuclear Organization · correlation 0.85
- RNA Splicing · correlation 0.81
- Hypoxia Response · correlation 0.80
- WNT Stem Cell · correlation 0.63
- AP-1 IEG Activation · correlation 0.63
- Ceramide Lipid Metabolism · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.