AP-1 IEG Activation
Gene co-expression module in Colorectal carcinoma
| Category | GF response |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical immediate early genes (IEGs) and AP-1 transcription factors: FOS, FOSB, JUN, JUNB, EGR1, NR4A1, ZFP36, ZFP36L2, IER2, BTG2. While FOS/JUN induction can indicate dissociation stress artifact, the co-expression with epithelial-specific genes (CLDN3, CLDN4, ELF3, ERBB3) and the CRC/WNT neighbor context (M66) strongly supports genuine AP-1/IEG activation in CRC tumor cells (e.g., RAS-ERK-driven AP-1 activation). SOX4 and GTF2I are transcription factors associated with CRC progression. The high mean expression (1.244) and 64% detection rate also argue against pure dissociation artifact.
Genes
Most correlated modules
- Dissociation Stress Response · correlation 0.85
- Epithelial Cell Junctions · correlation 0.75
- Hypoxia Response · correlation 0.73
- Golgi-Nuclear Organization · correlation 0.68
- RNA Splicing · correlation 0.66
- Colonocyte Differentiation · correlation 0.66
- Ceramide Lipid Metabolism · correlation 0.64
- Pre-mRNA Splicing · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.