Hypoxia Response
Gene co-expression module in Colorectal carcinoma
| Category | Hypoxia |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
WSB1 (WD repeat and SOCS box protein 1) is a substrate recognition component of an E3 ubiquitin ligase complex that targets VHL-interacting proteins and participates in HIF-1alpha regulation and hypoxia signaling. VEGFA is the canonical transcriptional target of HIF-1alpha and master regulator of angiogenic response to hypoxia. VMP1 is induced under hypoxia and mediates autophagy/ER stress responses. CCNL1 and DDX17 regulate transcription under stress. AKAP13 activates RhoA and has been linked to hypoxia-induced signaling. LLGL2 and DST are structural. The co-expression of WSB1 and VEGFA in a core coherent module strongly indicates a hypoxia-response program in CRC cells.
Genes
Most correlated modules
- Epithelial Cell Junctions · correlation 0.86
- Golgi-Nuclear Organization · correlation 0.86
- Pre-mRNA Splicing · correlation 0.80
- STAT3 Oncogenic Signaling · correlation 0.76
- RNA Splicing · correlation 0.76
- Epithelial Junctional Cytoskeleton · correlation 0.74
- AP-1 IEG Activation · correlation 0.73
- Colonocyte Differentiation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.