RNA Splicing
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes SF3B1 (U2 snRNP splicing factor), THOC2 (THO complex, mRNA export), SCAF11 (SR-related CTD-associated factor, splicing), HNRNPU (heterogeneous nuclear ribonucleoprotein U, RNA processing), and DDX5 (RNA helicase, splicing/processing) are all canonical RNA splicing and processing factors. ROCK2 and ATRX are outliers but may co-regulate chromatin-coupled transcription/splicing. CD46 is less clearly fitting. The core coherence and dominant RNA splicing hub genes make this a clear RNA splicing module.
Genes
Most correlated modules
- Ceramide Lipid Metabolism · correlation 0.84
- Golgi-Nuclear Organization · correlation 0.83
- Pre-mRNA Splicing · correlation 0.81
- WNT Stem Cell · correlation 0.78
- Hypoxia Response · correlation 0.76
- Ribosome Biogenesis · correlation 0.72
- ER Protein Processing · correlation 0.70
- Epithelial Cell Junctions · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.