Transcriptional Ubiquitin Regulation
Gene co-expression module in Colorectal carcinoma
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
POLR2K (RNA Polymerase II subunit K), ENY2 (component of SAGA/TREX-2 transcription/export complex), ELOC (Elongin C, part of CRL2 E3 ubiquitin ligase and transcription elongation), UBE2V2 (ubiquitin-conjugating enzyme variant), and ZNF706 point toward a transcriptional regulation and ubiquitin-mediated transcription control program. RHEB (mTOR activator) and YWHAQ (14-3-3 theta) add signaling context. MRPL13, COX6C, and UQCRB reflect the mitochondrial neighborhood. The module is a mixed housekeeping transcription/ubiquitin module.
Genes
Most correlated modules
- SUMOylation Pathway · correlation 0.89
- pre-mRNA Splicing · correlation 0.86
- Translation Initiation Factors · correlation 0.85
- Proteasome Degradation · correlation 0.83
- Mitochondrial Import & Complex I · correlation 0.81
- OxPhos Complex III/IV · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.