OxPhos Complex III/IV
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
COX7C, COX6B1, and COX5B are all cytochrome c oxidase (Complex IV) subunits. UQCRQ, UQCRH, and UQCR11 are ubiquinol-cytochrome c reductase (Complex III) subunits. Together these six genes define a tight oxidative phosphorylation Complex III/IV module. FAU (ubiquitin-like ribosomal protein) and BTF3 are peripheral housekeeping members. This is the most coherent OxPhos module in the batch and anchors the mitochondrial neighborhood.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.90
- SUMOylation Pathway · correlation 0.87
- Oxidative Phosphorylation ETC · correlation 0.86
- Mitochondrial Import & Complex I · correlation 0.86
- Core Cellular Machinery · correlation 0.84
- eIF3 Translation Initiation · correlation 0.83
- Proteasome Ubiquitin Degradation · correlation 0.82
- Translation Initiation Factors · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.