Proteasome Degradation
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
PSMA1, PSMA3, PSMB1 are alpha and beta subunits of the 20S proteasome core; UBE2N is a ubiquitin-conjugating E2 enzyme — together these define the ubiquitin-proteasome system (UPS). PTGES3 acts as a Hsp90 co-chaperone supporting proteasome assembly. MRPL47 (mitoribosomal) and SRP9 (SRP) are ancillary housekeeping genes. PRDX1 is a constitutive antioxidant. The dominant and coherent signal is proteasomal protein degradation, which is a core housekeeping/proteostasis program.
Genes
Most correlated modules
- pre-mRNA Splicing · correlation 0.91
- TRiC/CCT Core Complex · correlation 0.91
- hnRNP RNA Processing · correlation 0.90
- Mitochondrial OXPHOS · correlation 0.90
- SUMOylation Pathway · correlation 0.90
- Nuclear Assembly · correlation 0.90
- Housekeeping Mixed · correlation 0.90
- TRiC Chaperonin Complex · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.