pre-mRNA Splicing
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes LSM5, SNRPE, SNRPG, SNRPF, LSM3 are canonical Sm/LSm spliceosomal proteins forming the U snRNP core. RAN mediates nuclear transport of splicing factors. MRPL51, SSBP1, and TPRKB are housekeeping ancillary genes. The dominant program is pre-mRNA splicing. Uniform expression across all subsets and core coherence confirm constitutive housekeeping activity. Neighbor modules share similar mixed housekeeping character, reinforcing this classification.
Genes
Most correlated modules
- Mitochondrial Ribosome · correlation 0.92
- Nuclear Assembly · correlation 0.92
- RNA Processing & Biogenesis · correlation 0.92
- Proteasome Degradation · correlation 0.91
- Housekeeping Mixed · correlation 0.91
- SUMOylation Pathway · correlation 0.90
- Mitochondrial Assembly · correlation 0.90
- Nucleotide Biosynthesis · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.