SUMOylation Pathway
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes SUMO1 and SUMO2 are the defining members of the SUMOylation pathway. SF3B6 (a splicing factor known to be regulated by SUMOylation), DPY30 (SET1/MLL complex subunit, SUMO substrate), and PRDX6 are all involved in nuclear protein modification and maintenance. COX7A2L and SLC25A5 add minor mitochondrial signal but the dominant program is protein SUMOylation. All genes show uniform expression consistent with a constitutive housekeeping modification program.
Genes
Most correlated modules
- Mitochondrial Import & Complex I · correlation 0.90
- ER Protein Processing · correlation 0.90
- Proteasome Degradation · correlation 0.90
- pre-mRNA Splicing · correlation 0.90
- Housekeeping Proteostasis · correlation 0.89
- Transcriptional Ubiquitin Regulation · correlation 0.89
- Translation Initiation Factors · correlation 0.89
- OxPhos Complex III/IV · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.