Epithelial S100/Keratin
Gene co-expression module in Colorectal carcinoma
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Top hub genes include ANXA2, S100A10, S100A14, S100A11, S100A16 (S100/annexin family members central to calcium signaling, membrane organization, and invasion), KRT8, KRT18, KRT19 (simple epithelial keratins marking CRC tumor cells), LGALS3 (galectin-3, promotes tumor survival and invasion), ACTB and MYL6 (cytoskeletal), PKM (glycolytic enzyme), SFN (stratifin/14-3-3σ, tumor suppressor/adhesion), TMSB4X (actin sequestering). The S100/annexin/keratin combination is a hallmark of epithelial CRC cell identity with a cytoskeletal/invasive character. High mean expression and detection rate. This is a core CRC epithelial cell identity module, with S100 proteins also linked to invasion and metastasis. The cytoskeletal and housekeeping overlap is resolved by the prominence of invasion-associated S100 proteins and LGALS3.
Genes
Most correlated modules
- Endosomal Vesicle Recycling · correlation 0.86
- Clathrin-mediated Endocytosis · correlation 0.84
- Tight Junction Integrity · correlation 0.84
- Aerobic Glycolysis Warburg · correlation 0.82
- Growth Arrest Senescence · correlation 0.74
- Metabolic Stress Response · correlation 0.74
- ECM Invasion Program · correlation 0.67
- NF-κB Chemokine Response · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.