Endosomal Vesicle Recycling
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes RAB11A (recycling endosome GTPase) and VAPA (ER-endosome tethering) dominate the module, supported by ARF4 (Golgi ARF GTPase) and CDC42 (Rho GTPase regulating vesicle budding). MYL12A/B and CIB1 likely reflect actomyosin-driven vesicle transport. TSPO, NDUFV2, and VDAC2 are mitochondrial members that co-vary but represent a minority. The uniform expression and strong coherence point to a broad vesicular trafficking/endosomal recycling program active across CRC cells.
Genes
Most correlated modules
- Epithelial S100/Keratin · correlation 0.86
- Metabolic Stress Response · correlation 0.85
- Aerobic Glycolysis Warburg · correlation 0.84
- ER Protein Processing · correlation 0.82
- ER Protein Processing · correlation 0.82
- Endolysosomal Autophagy · correlation 0.81
- Proteasome Ubiquitin Degradation · correlation 0.81
- Clathrin-mediated Endocytosis · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.